Logistic and negative binomial regression analysis of article citation counts confirmed no citation advantage for open access articles. Fifty nine per cent of open access articles (146 of 247) were cited nine to 12 months after publication compared with 63% (859 of 1372) of subscription access articles. Open access articles were no more likely to be cited than subscription access articles in the first year after publication. Results Articles assigned to open access were associated with 89% more full text downloads (95% confidence interval 76% to 103%), 42% more PDF downloads (32% to 52%), and 23% more unique visitors (16% to 30%), but 24% fewer abstract downloads (−29% to −19%) than subscription access articles in the first six months after publication. Interventions Random assignment on online publication of articles published in 11 scientific journals to open access (treatment) or subscription access (control). Citations to articles were gathered from the Institute for Scientific Information after one year. Main outcome measures Article readership (measured as downloads of full text, PDFs, and abstracts) and number of unique visitors (internet protocol addresses). Participants 1619 research articles and reviews. Setting 11 journals published by the American Physiological Society. Objective To measure the effect of free access to the scientific literature on article downloads and citations. Lewenstein, Bruce V Simon, Daniel H Booth, James G Connolly, Mathew J L Open access publishing, article downloads, and citations: randomised controlled trial
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